CLL Leukemia Prognosis (Chronic Leukemia Prognosis)
CLL Leukemia Prognosis (Chronic Leukemia Prognosis) The prognosis for patients with CLL Leukemia (Chronic lymphocytic leukemia) is very difficult to anticipate with any level of accuracy due to difference in the rate of progression of the disease between individual variations regarding response to treatment and patients. CLL leukemia (Chronic lymphocytic leukemia) has a variable clinical course.
Evidence from research demonstrates that women with chronic lymphocytic leukemia have a tendency to respond better to treatment and survive longer than men. However the average survival rate of patients with CLL leukemia is approximately 10 years (5-10 years), in individual patients the Chronic leukemia prognosis is very variable, which range from a very short to a normal life span. So, some patient with chronic lymphocytic leukemia may have a good prognosis and may never require treatment, whereas in others the prognosis is bad and urgent treatment is needed.
There are several factors that affect the CLL leukemia prognosis (chance of recovery) include: the patient’s overall health, the patient’s response to treatment, the stage of the leukemia disease, whether a patient with CLL develops serious complications, the extent of spread of lymphocytes within the bone marrow. Though there are the various staging systems (Binet stages, Rai stages) which can be used to classify patients with CLL are very useful for determining the CLL leukemia prognosis, they aren’t accurate enough to indentify subgroups of patients with progressive chronic lymphocytic leukemia.
Evidence from research demonstrates that women with chronic lymphocytic leukemia have a tendency to respond better to treatment and survive longer than men. However the average survival rate of patients with CLL leukemia is approximately 10 years (5-10 years), in individual patients the Chronic leukemia prognosis is very variable, which range from a very short to a normal life span. So, some patient with chronic lymphocytic leukemia may have a good prognosis and may never require treatment, whereas in others the prognosis is bad and urgent treatment is needed.
There are several factors that affect the CLL leukemia prognosis (chance of recovery) include: the patient’s overall health, the patient’s response to treatment, the stage of the leukemia disease, whether a patient with CLL develops serious complications, the extent of spread of lymphocytes within the bone marrow. Though there are the various staging systems (Binet stages, Rai stages) which can be used to classify patients with CLL are very useful for determining the CLL leukemia prognosis, they aren’t accurate enough to indentify subgroups of patients with progressive chronic lymphocytic leukemia.
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1) Gender: There are numerous report of no difference in survival according to gender and others showing a better survival rate of women.
2) Age
3) Clinical Stage
3.1 Rai Stage
- Rai stage 0: characteristics - Lymphocytosis, risk low: average survival of patients is more than 10 years
- Rai stage I: characteristics - Lymphocytosis and lymphadenopathy, risk intermediate: average survival rate of patients is 5 years.
- Rai stage II: characteristics - Lymphocytosis and splenomegaly and liver enlargement, risk High: average survival rate of patients is 3 years.
- Rai stage III: characteristics - Lymphocytosis and Hb less than 11.0 g/dL, risk high, average survival rate of patients is 3 years.
- Rai stage IV: characteristics - Lymphocytosis and platelets less than 100 x 109/L, risk high, average survival rate of patients is 3 years.
3.2 Binet stage
- Binet A: characteristics - Hb > 10 g/dL, platelets > 100 x 109/L and < 3 lymph node areas, risk low, average survival rate of patients is more than 10 years.
-Binet B: characteristics - Hb > 10 g/dL, platelets < 100 x 109/L and >= 3 lymph node areas, risk intermediate, average survival rate of patients is 5 years
- Binet C: characteristics - Hb < 10 g/dL or platelets <100 x 109/L, risk high, average survival rate of patients is 3 years.
4) Lymphocyte Morphology
5) Immunodeficiency
Other factors for helping to determine to determine the chronic leukemia prognosis include Zeta-associated Protein 70 (ZAP-70), Lymphocyte Doubling Time, IgVH Gene status, Chromosomal Abnormalities, and CD38 antigen.
Latest news and CLL Leukemia Prognosis related articles
CMML Leukemia is a form of leukemia featuring monocytosis that usually occurs in children under age of 5. The symptoms of chronic myelomoncytic leukemia such as bruising, headaches, infection, sweating, pale skin, enlarged spleen and liver, enlarged lymph nodes and low platelet count.
Definition of Leukemia: In leukemia, the bone marrow generates a large number of abnormal white blood cells. These white blood cells don’t function properly (immature). malignant neoplasm of blood-forming tissues; characterized by abnormal proliferation of leukocytes; one of the four major types of cancer.
Leukemia VS Lymphoma: Lymphoma is a cancer in the lymphatic cells of the immune system. Leukemia is cancer of the white blood cells. Lymphomas are closely associated with lymphoid leukemias, that also originate in lymphocytes but typically involve only circulating blood and also the bone marrow
2) Age
3) Clinical Stage
3.1 Rai Stage
- Rai stage 0: characteristics - Lymphocytosis, risk low: average survival of patients is more than 10 years
- Rai stage I: characteristics - Lymphocytosis and lymphadenopathy, risk intermediate: average survival rate of patients is 5 years.
- Rai stage II: characteristics - Lymphocytosis and splenomegaly and liver enlargement, risk High: average survival rate of patients is 3 years.
- Rai stage III: characteristics - Lymphocytosis and Hb less than 11.0 g/dL, risk high, average survival rate of patients is 3 years.
- Rai stage IV: characteristics - Lymphocytosis and platelets less than 100 x 109/L, risk high, average survival rate of patients is 3 years.
3.2 Binet stage
- Binet A: characteristics - Hb > 10 g/dL, platelets > 100 x 109/L and < 3 lymph node areas, risk low, average survival rate of patients is more than 10 years.
-Binet B: characteristics - Hb > 10 g/dL, platelets < 100 x 109/L and >= 3 lymph node areas, risk intermediate, average survival rate of patients is 5 years
- Binet C: characteristics - Hb < 10 g/dL or platelets <100 x 109/L, risk high, average survival rate of patients is 3 years.
4) Lymphocyte Morphology
5) Immunodeficiency
Other factors for helping to determine to determine the chronic leukemia prognosis include Zeta-associated Protein 70 (ZAP-70), Lymphocyte Doubling Time, IgVH Gene status, Chromosomal Abnormalities, and CD38 antigen.
Latest news and CLL Leukemia Prognosis related articles
CMML Leukemia is a form of leukemia featuring monocytosis that usually occurs in children under age of 5. The symptoms of chronic myelomoncytic leukemia such as bruising, headaches, infection, sweating, pale skin, enlarged spleen and liver, enlarged lymph nodes and low platelet count.
Definition of Leukemia: In leukemia, the bone marrow generates a large number of abnormal white blood cells. These white blood cells don’t function properly (immature). malignant neoplasm of blood-forming tissues; characterized by abnormal proliferation of leukocytes; one of the four major types of cancer.
Leukemia VS Lymphoma: Lymphoma is a cancer in the lymphatic cells of the immune system. Leukemia is cancer of the white blood cells. Lymphomas are closely associated with lymphoid leukemias, that also originate in lymphocytes but typically involve only circulating blood and also the bone marrow